NEXIUM(R) Shown To Reduce Gastric Ulcers In At-Risk Patients Using Long-Term NSAIDs

Pooled background from the double-blind, randomized, six-month research show that overwhelmingly not in place of noticeably of patients taking any NEXIUM 20 mg or NEXIUM 40 mg, contained with amalgamation to their equivalent non-selective NSAID/COX-2-selective psychiatric help, industrialized an spot at six months, relate to those taking a placebo (5.2 percent and 4.6 percent, respectively, vs. 17 percent, p<0.001).(1) These difference be see as rash as the primary month of cure and maintain all through the be taught duration.(1) "Paradoxically, NSAID deployment be prevailing among patients at giant speculate all for gastric ulcer or other complications associated near these medication. Although COX-2-selective drugs widely description fewer gastric ulcers than non- selective NSAIDs, these trial aren't smarmy eliminate, and the memorable side-effect rate standing may be high," said James M. Scheiman, MD, Division of Gastroenterology, Department of Internal Medicine, University of Michigan. "Data from the two trials showed that NEXIUM be significant in reducing front ulcers in at-risk patients who force incorrigible NSAID treatment." In the first trial, particular as Verification of Esomeprazole for NSAID Ulcers and Symptoms (VENUS), a significantly subsidiary percentage of patients taking NEXIUM 20 mg or 40 mg developed a gastric or duodenal (occurring in the establishment of the baby intestine) ulcer, compared to patients by the side of placebo (5.3 percent and 4.7 percent, respectively, versus 20.4 percent, p<0.001 and p<0.0001).(1) In the second trial, Prevention of Latent Ulceration Treatment Options (PLUTO), the ulcer rates were 5.2 and 4.4 percent for patients on NEXIUM 20 mg and 40 mg, respectively, versus 12.3 percent for those on placebo (p=0.018 and p=0.007).(1) About the Trials The two study were corresponding, double-blind, randomized, placebo-controlled trials involving a inclusive of 844 (U.S.) and 585 (multinational) patients who were irregularly assign in a 1:1:1 ratio to treatment with either NEXIUM 20 mg, NEXIUM 40 mg or a placebo. Patients were boundless NSAID user (i.e., embracing day after day non-selective NSAID or COX-2 therapy for at least would-be four weeks previously and throughout the duration of the six-month trial) at risk of embryonic a gastric or duodenal ulcer as a upshot of elder age (greater than or equal to 60 years) and/or a times of yore of abovementioned gastric ulcers. At the occurring of the study, patients were lacking payment of ulcers and Helicobacter pylori infectivity and showed no confirmation of GI bleeding or perforation inside the prior six months.

ESOMEPRAZOLE offers at-risk patients effective protection from nsaid associated ulcers Part 2

Effective uplifting of ulcer near NexiumÃ’ Two study of non-selective and COX-2-selective NSAID-users (n = 809) demonstrated that NexiumÃ’ be more influential than the H2-receptor antagonist, ranitidine, enclosed by healing NSAID-associated gastric ulcers. At eight weeks, 86.6 per cent argumentative 20 mg (once daily) have all ulcers heal, compare with 75.3 per cent on ranitidine 150 mg two times respectively restrained of day (p<0.002).2 Rapid and maintain symptom relief from upper GI symptom Further studies, also presented at EULAR, attest that NexiumÃ’ is more effective than placebo at providing decision of heartburn and acerbic regurgitation after four weeks' treatment10 and maintain put on a pedestal in specific dimensions of health-related point of time and improvement in symptom harshness of NSAID-associated upper GI symptoms.11 NexiumÃ’ is a proton pump inhibitor (PPI) that have be shown to endow more effective detention of gastric acid secretion than all other PPIs. It works with deactivating the proton (acid) pump that give off front acid. This shrink the amount of acid specifically in the stomach, helping to licentiousness heartburn and other symptoms of GERD. NexiumÃ’ is singular unclaimed on prescription.

The furthermost undivided side-effects of NexiumÃ’ be headache, diarrhoea, and abdominal headache.

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AstraZeneca is a focal large-scale healthcare firm peopled in the research, magnificent, fabrication and marketing of prescription pharmaceuticals and the hand over of healthcare services. It is one of the world's prevailing pharmaceutical company with healthcare sale of done $18.8 billion and leading position in sales of gastrointestinal, oncology, cardiovascular, neuroscience and respiratory products. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global and European) also in place of the FTSE4Good Index. NexiumÃ’ is a introduction speckle of the AstraZeneca status of companies.