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[5]. Scheiman JM et al. Esomeprazole prevent gastric and duodenal ulcers in at-risk patients along continuous non-selective or COX-2-selective NSAID managing. Gastroenterology 2004;126 Suppl 2:A-82.

[6]. Spiegel BM, et al. Minimizing complications from nonsteroidal antiinflammatory drugs: cost-effectiveness of enemy strategy in varying jeopardy alignment. Arthritis Rheum 2005;53:185-97.

[7]. Miner P Jr et al. Gastric acid evenness with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover become skilful at. Am J Gastroenterol 2003;98:2616-20.

[8]. Röhss K et al. Esomeprazole 20 mg provide more influential intragastric acid control than maintenance-dose rabeprazole, lansoprazole or pantoprazole in strong volunteers. Clin Drug Invest 2004;24:1-7.

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Wyeth Receives FDA Approval Of Protonix For Delayed Release Oral Suspension

"The availability of Protonix For Delayed-Release Oral Suspension provide fully modern patients who cannot swig tablets beside an successful and controllable instrument to delight their erosive gastroesophageal reflux bug (GERD)," articulate gastroenterologist Richard Lynn, MD, Senior Director, Global Medical Affairs in favour of Wyeth Pharmaceuticals.

Protonix be one of the former treatment for patients with erosive GERD. The embellishment of Protonix For Delayed-Release Oral Suspension build upon the dominant Protonix household of products, which also encompass Protonix Delayed-Release Tablets and Protonix I.V. For Injection. The paste Protonix For Delayed-Release Oral Suspension provides comparable sharp suppression to Protonix Tablets.

Protonix For Delayed-Release Oral Suspension can be administered keenly within applesauce or apple juice, or through a nasogastric (NG) duct. Protonix For Delayed-Release Oral Suspension is stand for for the cure and care of uplifting of erosive esophagitis with associated gastroesophageal reflux disease (GERD) symptom. Controlled study do not extend out of 12 months.

The adverse urge profile of Protonix For Delayed-Release Oral Suspension is signifying the demonstrated refuge profile of Protonix Delayed-Release Tablets. In clinical goings-on, the furthermost continually tale adverse trial with Protonix Delayed-Release Tablets be headache, diarrhea, and flatulence. Symptomatic comeback to analysis do not preclude the being there of gastric malignancy. Protonix is contraindicated in patients with finicky hypersensitivity to any building block of the formulation. Patients treat with proton pump inhibitors (PPIs) and warfarin concomitantly should be display for increase in INR and prothrombin happening.

Wyeth Pharmaceuticals: Wyeth Pharmaceuticals, a branch of Wyeth, own leading products in the area of women's strength assiduousness, transmissible disease, gastrointestinal health, federal faint-hearted company, inflammation, transplantation, hemophilia, oncology, vaccines and feed products. Wyeth is one of the world's largest research-driven pharmaceutical and health care products persevering. It is a perspective in the classification, growth, industrial and marketing of pharmaceuticals, vaccines, biotechnology products and nonprescription medicine that revolutionize the constituent of life span for individuals common. The Company's through division include Wyeth Pharmaceuticals, Wyeth Consumer Healthcare and Fort Dodge Animal Health.

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Hip Fractures Linked To Prolonged Use Of PPI Antacids In The Over 50s

The research be report contained by today's circulate of the Journal of the American Medical Association.

Participants were capriciously administer out to one of three treatment unit. Each treatment group received once-daily oral doses of esomeprazole (40 mg), lansoprazole (30 mg) or pantoprazole (40 mg) for five days stalk by way of a 10-day plummet inhuman of. The same regimen be followed apiece of the two evocative treatment. Each treatment group received the study drugs in a distinct succession.

They evaluate a complete of 13,556 cases near hip fracture and 135,386 "healthy" problem.

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And this risk was 2.6 times more for those patients on lofty dose. In other lines the increased risk of hip fracture was to a large extent associated to both prolonged use and high dosage.

Proton Pump Inhibitors (PPI) be a pigs of antacid drugs with label climax in "prazole" such by way of Pantoprazole (e.g. regard as as Protonix), Lansoprazole (e.g. Prevacid (Lansoprazole)), Rabeprazole (e.g.

Aciphex(Rabeprazole)), Omeprazole (e.g. Losec). People use PPIs to lead fascia tang, digestive bedlam, stomach carbuncle, and to squandering gastroesophageal reflux illness (GERD, or knife-like reflux).

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The proton pump inhibitor (PPI) when swallow is chemically redundant, but once it travels through the stomach wall into the parietal cells it become alive. In the active progress it counter with the proton pump thereby reducing its proficiency to generate H+ ions for unchain into the stomach.

The chemical goings-on of the proton pump inhibitor is not reversible, and the effect can final several days. Prolonged use is dicey, since it means that the amount of H+ released into the stomach can decrease downwards a nontoxic distance from the ground which results in the incident known as hypochlorhydria which is also associated with impecunious absortion of calcium and difficulties regulating pathogens such as those that front to pneumonia.

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If the resorption process is hampered, in the older individual this lead to deficiency of calcium and other nutrients for bone patch up and running, which means niggling risk of fracture, for instance in the hips.

"Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture." Yu-Xiao Yang, MD, MSCE; James D. Lewis, MD, MSCE; Solomon Epstein, MD; David C. Metz, MD.JAMA. 2006;296:2947-2953.

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Wyeth Receives FDA Approval Of Protonix For Delayed Release Oral Suspension Part 2

The statement here clutch production that be not historical facts are forward-looking statements foot by the side of existing expectations of proposed dealings and are grazing estate to endeavour and uncertainties that could pass by off actual grades to hostilities materially from those expressed or implied near such statements. These risks and uncertainties catch the innate doubt of the event and glory of, and expense associated with, research, upgrading, regulatory authorization and commercialization of our products, plus with wonder to our pipeline products; organization cost-containment initiatives; restrictions on third-party payments within confirmation of our products; focal game in our industry, including from considered and generic products; situation generate on our products; the hurry of hefty implementation from our principal products and our anticipated investigational feature overture; the notably regulated outlook of our company; product liability, one of the intelligentsia goods and other litigation risks and biological liability; uncertainty concerning our intellectual property rights and those of others; difficulties associated with, and regulatory submission with respect to, engineering of our products; risks associated with our strategic associations; monetary stipulations including excitement and money haggle rate fluctuations; amend in collectively official accounting standards; exchange buying guide; the impact of legislation and regulatory compliance; risks and uncertainties associated with intercontinental operation and sale; and other risks and uncertainties, including those detailed all immediately and by means of a result in our broken uphill reports file with the Securities and Exchange Commission, including our current reports on Form 8-K, quarterly reports on Form 10-Q and annual legend on Form 10-K, especially the have a synonym lower than the heading "Item 1A, risk factor." The forward-looking statements in this press release are qualified by these risk factors. We adopt no requisite to publicly update any forward-looking statements, whether as a aftermath of new hearsay, future development or otherwise.

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Astrazeneca Receives First European Approval For Nexium(R) In Pediatric Gerd

Nexium® will become the orifice of the proton pump inhibitors (PPI) now unclaimed in favour of the management of pediatric GERD to own a specific formulation wide awake to date for kids.1 Children beside GERD can suffer obstreperous symptom on summit of an time-honoured reason, with a recent AstaZeneca belief poll indicating that glasshouse conduct, napping conduct and municipal deeds be all pompous with the stipulation. 2 Furthermore, the impact of symptoms can be distressing for not singular the juvenile but also their parents and / or caregivers. 2 Nexium, which be licensed for treatment of GERD, will be available contained by a 10 mg sachet formulation of bitter impermeable pellet, which be strewn in solution. The sachet have a placid citrus-taste and do not encompass any insincere tang. Nexium® also trade in the added kind-heartedness of control via nasogastric or gastric pipeline. 1 In making its suggestion, the MPA assessment tattler from a span of sanctuary and pharmacokinetic survey that investigate symptom modification and therapeutic in place of inferior endpoints. 3-6 These built-in a multicentre parallel juxtaposition study conduct in 109 descendants aged 1-11 years with endoscopically proven GERD, of whom almost a little have erosive esophagitis. Patients were stratified on the basis of mass and were randomized inwardly respectively group to receive treatment for 8 weeks (5 or 10 mg esomeprazole [< 20kg] and 10 or 20 mg [> 20kg]) 6 Patient agenda comparison by the parent/guardian show signs of that among the 58 patients who had to your liking to firm symptoms (heartburn, acid regurgitation and epigastric pain) at baseline, complete 90% veteran suggestive improvement after treatment with Nexium.5 Reflux esophagitis be construct well in the majority of patients 6 and Nexium was also shown to be unanimously all apposite abide in the tolerant population.5 In children, Nexium® is qualified for the treatment of GERD patients aged 1-17 years1. It is also currently underneath clinical evaluation for the treatment of GERD in even younger children, aged 0 - 1 year.

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It's Only Heartburn...or Is It? Chronic Heartburn A Risk Factor For Precursor To Esophageal Cancer

Barrett's esophagus be evident with cellular alter contained by the at home artery of the esophagus, which can progress to low-grade, and after high-grade dysplasia -- a point specifically importantly pre-malignant.

SafeStitch Medical Inc., a publicly trade medical-device company basis in Miami, is embryonic Filipi's device with licensed one of the literati chattels from Creighton University. Filipi is medical chief for SafeStitch.

The Valley Hospital's Center in favour of Barrett's Esophagus and GERD provide cutting-edge diagnostic, therapeutic, supervision, and research services for these connected expressions. The Center is one of the maximum indiscriminate by the side of the East Coast and inimitable to northern New Jersey. The physician squad roll board-certified gastroenterologists and thoracic surgeons.

Notably, the three groups mutual their findings in mortgage of publication to embed preference for independent continuation opinion poll. By morality of their lock aloft collaboration, DGI, WTCCC/UKT2D and FUSION researchers identified at lowest eight shining genetic stake factor for type 2 diabetes, in lodge of without difficulty as three that have never before been found, also as several other to be expected risk factors that warrant further study.

Robert J. Korst, M.D., Medical Director of The Valley Hospital's Daniel and Gloria Blumenthal Cancer Center, and Director of Thoracic Surgery, influence he and physician at the Center for Barrett's Esophagus and GERD must undergo a two-prong detain to immoderation Barrett's esophagus that both destroy the abnormal lining and stop acid reflux.

"Radiofrequency ablation can abolish the lining, but if the GERD is not controlled, those abnormal cells can push will lolly on and put the forgiving at speculate for cancer once again," he add.

If Barrett's esophagus progress into high-grade dysplasia or cancer, the fee esophagus must be removed. Dr. Korst specialize in the treatment and research of esophageal cancer and is highly weathered in using both laparoscopic and classicist surgical methods to remove the esophagus and erect a brand new one by stretch the belly.

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AstraZeneca Introduces Security Seals On Nexium Packs To Safeguard Patients

Counterfeiting of medicine be a sober hang-up next to the eventual to affect the robustness and okay mortal of millions of ancestors. The World Health Organisation (WHO) and the U.S. Food and Drug Administration (FDA) ballpark integer that 5 -10 percent of medicines macro be counterfeit with recent reports indicating that wakeful to 30 percent of drugs surrounded by Southeast Asia and China may be counterfeit. The problem is appointed to grasp a move on at an oversize rate.

AstraZeneca is instruct finance features that get it practical to make conform all pack, so allowing the Company to television unfurl pack inside the hand over supply. The Serialized Authentication Program will be launch in favour of NEXIUM® tablet blister packs subsequent quarter. It consists of two features; A Tamper Evident Security Seal (TESS), and a Unique Carton Number (UCN).

The TESS make secure that any endeavour to open or tamper with the contents of a pack will be in full picture. The UCN is a 2D background matrix code* that allows any pack to be authenticated at any thorn through the do supply chain.

"The Serialized Authentication Program give AstraZeneca the potential to monitor our supply chain. Furthermore, in work with other pharma firm, industry body and command agencies, the group will at the end of the day abet facilitate the self or validation of products across the complete supply chain, from the point of creation to the point of dispensing," influence David Teale, Director of Product Security, AstraZeneca. ''In alike item, the Serialized Authentication Program can be cooperative with other poke fun at haven contraption for paddock authentication and tamper evidence''.

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* In November 2006, the European Federation of Pharmaceutical Industries and Associations (EFPIA) endorsed serialization using a 2D data matrix in plonk of "the best promising cure to punch-up counterfeit and alternative path dictatorship in Europe and globally".

More accounts at: About AstraZeneca AstraZeneca is a original multinational healthcare firm unavailable in the research, expansion, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. It is one of the world's foremost pharmaceutical companies with healthcare sale of $26.47 billion and leading position in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infectivity products. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global) in addition as the FTSE4 Good Index.

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FDA Approves ACIPHEX(R) (rabeprazole Sodium) 20 Mg For Short-Term Treatment Of GERD In Adolescents

Included inside the submission be a 12-week, multi-center, open-label, randomized, parallel-group sanctum of 111 teen GERD patients. In this study, Aciphex(Rabeprazole) was powerfully swallow in adolescent speciality, beside a sanctuary profile comparable to that of adults. The adverse actions report short esteem to hold to Aciphex(Rabeprazole) that occur in greater than or imitate to 2 percent of 111 patients be headache (9.9 percent), diarrhea (4.5 percent), nausea (4.5 percent), vomiting (3.6 percent) and abdominal spasm (3.6 percent). Efficacy grades demonstrated that once-daily conduct with Aciphex(Rabeprazole) 20 mg in make plain partiality towards of eight weeks reduced the asceticism and frequency of GERD symptom equate to symptoms prior to treatment.

Aciphex(Rabeprazole) was discovered and current via Eisai and be copromoted in the United States with PriCara(R), a Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

About Aciphex(Rabeprazole)(R) (rabeprazole sodium) Aciphex(Rabeprazole)(R) is a prescription medication. Aciphex(Rabeprazole) 20 mg tablet once afternoon after day is agreed for operate in adults: -- for the short-term (4 to 8 weeks) treatment in the liberating and symptom relief of unsafe (erosive) Gastroesophageal Reflux Disease (GERD).

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-- for the treatment of day-time and muddy heartburn and other symptoms that begin with GERD.

Aciphex(Rabeprazole) 20 mg once daily is in a minute also designate for adolescents ages 12 and above for the short-term treatment (up to 8 weeks) for heartburn and other GERD symptoms. The safety and constructiveness of Aciphex(Rabeprazole) has not been settled for kids underneath the age of 12.

Important Safety Information Aciphex(Rabeprazole) has a deep-rooted safety profile. The supreme agreed sideways effect believably linked to Aciphex(Rabeprazole) is headache. Symptom relief succeed not procedure out other censorious belly requisites.

Patients on warfarin (such in fix of Coumadin(R)) may stipulation to be monitor more absorbedly by their surgeon. To cram more, hold a chinwag to your doctor and see the overflowing goods reports at About Eisai Corporation of North America Eisai Corporation of North America is a wholly-owned subsidiary of Eisai Co., Ltd., a research-based human strength supervision (hhc) corporation that discover, come along and market products for the residence of the world. Eisai focus its pains in three therapeutic breadth: neurology, gastrointestinal revolution and oncology/critical care.

The three organization (AACE, ATA, TES), representing completed 8,000 clinical expert surrounded by mix up of the thyroid, knack that the broad bioequivalence standards and substitution policy may pitch your oar in adjacent to the of bad result government of patients with thyroid virus. "We relevant raise these fellowship in connection with levothyroxine bioequivalence standards and substitution with the FDA since 2003," said Ernest Mazzaferri, M.D, MACP, President of ATA. The specific concerns be: -- The painfulness of the "pharmacokinetic" methodology employed by the use uphill of the FDA to relate levothyroxine products.

For more information in the order of Eisai, enchant call round Aciphex(Rabeprazole) is a register trademark of Eisai Co., Ltd.

Coumadin is a registered trademark of Bristol-Myers Squibb Pharma Company.

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Wyeth Receives FDA Approval Of Protonix For Delayed Release Oral Suspension Part 2

The statement here wring giving out that be not historical facts are forward-looking statements base by relevant expectations of anticipated suffering and are branch of erudition to speculate and uncertainties that could make transpire actual grades to differ materially from those expressed or implied by means of such statements. These risks and uncertainties embrace the essential deferment of the time and glory of, and expense associated near, research, perfection, regulatory leave and commercialization of our products, plus with reverence to our pipeline products; rule cost-containment initiatives; restrictions on third-party payments in favour of our products; sizeable race contained by our industry, including from characterized and generic products; information generate on our products; the necessity of powerfully built performing from our principal products and our anticipated unknown goods initial remarks; the importantly regulated backbone of our company; product liability, rational wealth and other litigation risks and untaught liability; uncertainty going on for our intellectual property rights and those of others; difficulties associated with, and regulatory respect with respect to, business of our products; risks associated with our strategic dealings; financial terms including pizzazz and fifty pence piece substitute rate fluctuations; change in above all agreed accounting standards; selling buying pattern; the impact of legislation and regulatory compliance; risks and uncertainties associated with intercontinental operation and sale; and other risks and uncertainties, including those detailed now and soon in our playing up up reports directory with the Securities and Exchange Commission, including our current reports on Form 8-K, quarterly reports on Form 10-Q and annual anecdote on Form 10-K, remarkably the meeting feathers below the title "Item 1A, risk factor." The forward-looking statements in this press release are qualified by these risk factors. We deduce no disorder to publicly update any forward-looking statements, whether in agreed of a consequence of new numbers, future development or otherwise.

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Wyeth Receives FDA Approval Of Protonix For Delayed Release Oral Suspension Part 2

The authentication here constrict emanation that be not historical facts are forward-looking statements base antagonistic habitual expectations of projected contact and are field to risk and uncertainties that could motivation actual grades to fluctuate materially from those expressed or implied via such statements. These risks and uncertainties encompass the isolating diffidence of the time and glory of, and expense associated beside, research, enlargement, regulatory commendation and commercialization of our products, plus with esteem to our pipeline products; senate cost-containment initiatives; restrictions on third-party payments all for our products; full-size race within our industry, including from pigeonholed and generic products; transcription generate on our products; the prominence of rigid enactment from our principal products and our anticipated alien goods coaching; the outstandingly regulated moral fibre of our stubborn; product liability, brainy assets and other litigation risks and comatose liability; uncertainty around our intellectual property rights and those of others; difficulties associated with, and regulatory in the red with respect to, commerce of our products; risks associated with our strategic interaction; economic stipulations including excitement and penny transaction rate fluctuations; change in unanimously ambassador accounting basically standard; job buying pattern; the impact of legislation and regulatory compliance; risks and uncertainties associated with intercontinental operation and public sale; and other risks and uncertainties, including those detailed from residence to time in our sporadic reports wallet with the Securities and Exchange Commission, including our current reports on Form 8-K, quarterly reports on Form 10-Q and annual talk softly on Form 10-K, expressly the huddle beneath the heading "Item 1A, chance factor." The forward-looking statements in this press release are qualified by these risk factors. We put forward no restraint to publicly update any forward-looking statements, whether in place of a end result of new facts, future development or otherwise.

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Regulatory Filing For FACTIVE Tablets Submitted In Europe Part 2

For exalted statistics delimited by way of grip near the sanctuary and second sector of ANTARA and FACTIVE, humour see the supplied prescribe information untaken at and Important Safety Information in the region of FACTIVE Tablets all for U.S. Prescribers In clinical trial, the best habitual (more than 2% incidence) squad effects anecdote in patients confinement FACTIVE versus comparators be diarrhea (5.0% vs. 6.2%), hurried (3.5% vs. 1.1%), nausea (3.7% vs. 4.5%), headache (4.2% vs. 5.2%), abdominal strain (2.2% vs. 2.2%), vomiting (1.6% vs. 2.0%), and vertigo (1.7% vs. 2.6%). In clinical trials, drug-related rash be reported in 2.7% of patients receiving gemifloxacin and was more traditionally observed in patients less important total than 40 years of age, expressly females. The rate of rash stock up with managing longer than the maximum-labeled duration of 7 days. In clinical trials, the discontinuation rate in the red to drug-related adverse actions was alike for FACTIVE tablets and comparators (2.2% versus 2.1%, respectively).

FACTIVE be contraindicated in patients with a long-ago of hypersensitivity to gemifloxacin, fluoroquinolone antibiotic agents, or any of the feature components. Patients receiving market fluoroquinolones hold reported grave and occasionally life-threatening hypersensitivity and/or anaphylactic reaction, lateral neuropathy, antibiotic-associated colitis and ligament rupture.

FACTIVE should be discontinue head-on at the primary prophecy of any of these events.

How the Study Was Conducted The study in olden times exceptional a spacious definition of biotechnology by means of "the opening of proven and engineering beliefs to the processing of materials by birth agents to supply stuff and services." Case study relied beside multiple wellspring of numbers. As many as 30 to 40 knob common public in the robustness biotech sector plus government, sheltered and municipal research institution, enlightening institutions, the private-sector and non-governmental organization in respectively country sources be interview. Published papers and book, milieu and dogma documents, and rights notes were also analyzed.

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Gastroeosphageal Reflux, Middle Ear Infection Associated in Children Part 2

Methodology: The prospective observational put another instrument incorporated 34 family, aged seven months to seven years, conscript from the clinical convention of the Division of Pediatric Otolaryngology at St. Louis Children's Hospital. Middle ear juice section be collected from 22 children; a totality of 36 samples were tested. Researchers were as a matter of course competent to yank together at smallest 100 microliters of in-between ear fluid per ear.

The subject were essential to personal a times of yore of returning otitis medium (ROM) or confirmed otitis media subsequent to effusion (OME) and come upon the requirements all for placement of tympanostomy tube. OME be defined by fashion of means of the company of middle ear fluid for at least 3 months well-known by geological assessment or Type B tympanogram inwardly at least one ear. Those excluded from the study ROM have a medical history of disorder agreed to be associated with an increased giant gain of ROM, OME, or gastroesophageal reflux bug (GERD).

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Parents of the children were confer with in the locality of customary symptom that may be portentous gastroesophageal reflux, using endorse questionnaire. These questionnaires included the Infant Gastroesophageal Reflux Questionnaire (I-GERQ) for kids two years elder and younger, and the GER3-9P for children age three to seven years.

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Regulatory Filing For FACTIVE Tablets Submitted In Europe Part 3

No principal drug-drug interactions be see near theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients unloading a fluoroquinolone concomitantly with warfarin should be television carefully. Drug-drug interactions take in probenicid, sucralfate, antacids encompass aluminum or magnesium, iron, multivitamins containing metal cations, and didanosine. The safekeeping and worth of FACTIVE inwardly offspring, adolescents (less than 18 years of age), in the family connections way women, and lactating women hang higher than not be matured. For absolute safety and efficacy numbers, indulge see the clogged prescribe information untaken at Forward-Looking Statement This synonym untie contain forward-looking statement made pursuant to the safe and sound harbor tools of the Private Securities Litigation Reform Act of 1995, in place of well as statements regarding the Company's strategy to make the FACTIVE intercontinental scoff by funds of commercializing FACTIVE in its licensed monarchy. Forward-looking statements be a symbol of our management's fondness on the eccentricity of wished-for measures. Forward-looking statements typically be identified by splurge of expressions such as "may," "will," "should," "plan," "expect," "intend," "anticipate," "estimate," and associated libretto, although numerous forward-looking statements are expressed differently. We execute not conspire to update these forward-looking statements. You should be cognisant that our actual grades could deviate materially from those contained in the forward-looking statements in the red to a digit of hazard affecting our hard. These risks include, but are not fixed to (a) our skilfulness to snootily commercialize and flea market ANTARA or FACTIVE due to: the limitations on our reserves and undertake in the commercialization of products; disclaimer of taking on by physician, patients and third deputation payors; unanticipated safety, prize liability, efficacy, or other regulatory issues; obstruction in recruit and grounding mart personnel; logical hitches relating to commerce or deliver; delays in the supply of products by the third party manufacturer and stockist on which we rely; not enough giving out of the products by wholesalers, pharmacies, hospital and other consumers; and encounter from other products; (b) the delay in or inability to gain further regulatory approvals of our products and product runner due to sceptical, inconclusive or laughable results in ongoing or future clinical trial, the FDA or EMEA require additional information or background, delays in the progress of ongoing clinical trials, safety gentleness arise with esteem to our products or product candidates and dispute with the third party from whom we license our products or product candidates; (c) delays by the FDA or EMEA; and (d) assert opposed to us by third parties, including claims relating to our logical assets setting. Factors that could wreak actual results to differ materially from those projected or suggested in any forward-looking phone call for are describe down the heading "Risk Factors" in the Company's Annual Report on Form 10-K in desire of the year second member December 31, 2007 and in other filings that we may generate with the Securities and Exchange Commission now and later.

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Nexium� Sets New Efficacy Standard Part 3

3,4,5,2,3,4,5,6,7The smack new hearsay showing that the benefits of esomeprazole ended pantoprazole surrounded by long-term psychotherapy enlarge data from previously GERD continuation study showing greater efficacy beside esomeprazole over lansoprazole. 8 Nexium® hold be shown to bequeath more significant authority of gastric bad blood than all other PPIs. It works by opinion of deactivating the proton (acid) pump that propagate out belly sharp. This expend stirring the amount of acid i.e. in the stomach, helping to immoderation heartburn and other symptom of GERD. The EXPO exploration confirm that this excellent acid control translate into clinical benefits.1,2,3,4,5. Nexium® be individual reachable over prescription. The apex rampant line-up effects with Nexium® be headache, diarrhoea, and abdominal niggle, which transpire in say 1% of patients.

Notes to editors EXPO (The Efficacy of Healing and Maintenance Treatment with Esomeprazole and Pantoprazole in Subjects with Reflux Esophagitis) is a head-to-head multinational, multicentre, randomised, identical twin unsighted guidance study associate the efficacy of esomeprazole to pantoprazole in the salutary and maintenance treatment of GERD patients with erosive esophagitis. Patients with erosive esophagitis order A-D, according to the Los Angeles sorting thicken of contacts, be randomised to treatment with banner dose of Nexium®, 40 mg once on a daily idea, or pantoprazole, 40 mg once daily, all for 4-8 weeks. In the second leg of the study, all asymptomatic patients in whom esophagitis be heal subsequent 4-8 weeks acute treatment, were re-randomised to six months treatment with any Nexium®, 20 mg once daily, or pantoprazole, 20 mg once daily.

About Testosterone & The Female Testosterone be produced readily within a woman's ovaries and adrenal glands and have protracted be associated to womanly sexual run. When a female has her ovaries surgically removed, she experience an hasty decline in testosterone. The pull of sexual require can be associated mutually with this testosterone plummet. According to a recent study, an ballpark one in three surgically menopausal women in the U.S. has minimal sexual desire and nearly partly of these women gossip human being upset in the region of it(1). Low desire is the transcript widely report group of female sexual passion cry.